Searchable abstracts of presentations at key conferences in endocrinology

ea0029p615 | Diabetes | ICEECE2012

The role of AMP-activated protein kinase in myocardial tolerance to ischemia in rats with diabetes mellitus type 2 and its relation to metformin therapy

Kravchuk E. , Grineva E. , Galagudza M. , Kostareva A.

Introduction: The aim of our experimental study was to investigate the effect of both T2DM and metformin treatment on myocardial tolerance to ischemia-reperfusion injury and cardiac AMP-activated protein kinase (AMPK) activity.Methods: The protocol included four groups: i) controls (n=13) – non-diabetic rats treated with i.p. vehicle injections for 3 days prior to the heart perfusion, ii) controls+metformin (CM; n=12) – non-diabet...